CD146, a multi-functional molecule beyond adhesion.

CD146: a new partner for VEGFR2.

Arbiser JL. Efficacy of topical application of eosin for ulcer-ated hemangiomas.macologic blockade of Angiopoietin-2 is efficacious against model hemangiomas in mice. In this issue of Blood, Jiang et al identify the cell adhesion molecule CD146 as novel co-receptor for vascular endothelial growth factor receptor 2 (VEGFR2). 1 T he cell adhesion molecule CD146 was first described in 1987 because...

IL-17A production in human psoriatic blood and lesions by CD146+ T Cells

CD146, also called melanoma cell adhesion molecule (MCAM), is a cell surface adhesion molecule on endothelial cells involved in homotypic and heterotypic cell interactions (Bardin et al, 2001). CD146 binding in endothelial cells (ECs) leads to a change in cellular permeability, actin distribution and redistribution of NF-kappa B p50 to the nucleus. CD146 has been shown to be present on 1–3% of ...

A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule

CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting...

Receptor Lymphocyte and Is an Endothelial Adhesion Promotes Rolling via Microvilli Induction in Endothelium Interaction: MCAM/CD146 Molecule (MCAM)/CD146 in Lymphocyte Dual Role of Melanoma Cell Adhesion

Blockade of adhesion molecule CD146 causes pregnancy failure in mice.

Unexplained pregnancy loss and recurrent miscarriage seriously impair human fecundity. However, the underlying molecular mechanisms remain elusive. Recent studies suggest that the adhesion molecule CD146 may be involved in unexplained recurrent miscarriage. Here, we investigate the effect of CD146 on early pregnancy. Using in situ hybridization and immunohistochemistry, we found that CD146 was ...